GNE-490, CAS 1033739-92-2

Formulation: A solid

Formal Name: 2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine-6-methanol

Purity: ≥98%

Formula Markup: C18H22N6O2S

Formula Weight: 386,5

Shelf life (days): 1460

CAS Number: 1033739-92-2

Notes: GNE-490 is an inhibitor of PI3K (IC50s = 3.5, 25, 5.2, and 15 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively).{24603} It is selective for PI3K over mTOR (IC50 = 740 nM) and a panel of 142 kinases at 1 µM. GNE-490 (0.4 µM) reduces cell migration by, the number of vessel outgrowths from, and induces apoptosis in, human umbilical vein endothelial cells (HUVECs).{66815} It increases the length of circadian rhythms in zebrafish larvae.{66816} GNE-490 (30 mg/kg) decreases vascularization and tumor growth in a PC3 prostate cancer mouse xenograft model.{66815}

• SKU: CAY41120-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41120-1
• Package Unit: 1 mg
• Quantity Unit: STK