GPX4 24, CAS 2920221-53-8

Shelf life (days): 1095.0

Formulation: A solid

Formal Name: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methylsulfonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester

Purity: ≥98%

Formula Markup: C22H21ClN2O5S

Formula Weight: 460.93132

CAS Number: 2920221-53-8

Notes: GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Item No. 19288).{65719} It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases kidney and plasma malondialdehyde (MDA) levels in mice when administered at a dose of 200 mg/kg.

• SKU: CAY38428-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38428-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe