Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human GRN
Molecular Weight: 48kDa
Peptide Sequence: Synthetic peptide located within the following region:
QAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Granulins
Protein Size: 438
Purification: Affinity purified
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