Target: GRP170
Conjugate: FITC
Product Type: Monoclonal
Clone Number: 6E3-2C3
Immunogen: Recombinant Full length Human GRP170 Protein
Swiss-Prot: Q9Y4L1
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~170kDa.
Cellular Localization: Endoplasmic Reticulum,Endoplasmic Reticulum Lumen
Scientific Background: GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2).
References: 1. Wang H., et al. (2014) Front Oncol. 4: 377.2. Manjili M.H., et al. (2006) Immun. Cell Biol. 84: 203-208.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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