GS-444217, CAS 1262041-49-5

Formulation: A solid

Formal Name: 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C23H21N7O

Formula Weight: 411,5

Shelf life (days): 1460

CAS Number: 1262041-49-5

Notes: GS-444217 is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 2.87 nM).{67744} It is selective for ASK1 over 442 additional kinases at 1 µM. GS-444217 (0.001-10 µM) inhibits phosphorylation of the ASK1 substrates MAP kinase kinase 3 (MKK3), MKK6, and MKK4, as well as their downstream substrates p38 MAPK and JNK in HEK293T cells expressing human ASK1. Dietary administration of GS-444217 (0.3% w/w) reduces renal fibrosis and proteinuria in a db/db eNOS-/- mouse model of diabetic kidney disease (DKD).

• SKU: CAY40757-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40757-10
• Package Unit: 10 mg
• Quantity Unit: STK