GSK329, CAS 1268490-12-5

Formulation: A solid

Formal Name: N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N′-[3-(trifluoromethyl)phenyl]-urea

Purity: ≥98%

Formula Markup: C19H14Cl2F3N5O2

Formula Weight: 472,3

Shelf life (days): 1460

CAS Number: 1268490-12-5

Notes: GSK329 is an inhibitor of cardiac troponin I-interacting kinase (TNNI3K; IC50 = 10 nM) and a derivative of the multi-kinase inhibitor sorafenib (Item Nos. 10009644 / 35612).{68721} It is selective for TNNI3K over VEGFR2, p38α, and B-RAF (IC50s = 400, 800, and >2,000 nM, respectively). In vivo, GSK329 (2.75 mg/kg) reduces superoxide levels in isolated left ventricular tissues and infarct size in a mouse model of myocardial ischemia-reperfusion injury induced by left anterior descending (LAD) coronary artery occlusion.{68722}

• SKU: CAY40666-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40666-5
• Package Unit: 5 mg
• Quantity Unit: STK