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Background: GSK3 (Glycogen synthase kinase) is a serine/threonine kinase which initially was found to phosphorylate and inactivate glycogen synthase in glycogen biosynthesis. It is an important regulator enzyme in many disease pathogeneses including cancer, immune disorders, metabolic disorders and neurological disorders like Alzheimer's disease. In fact, GSK3β, one of the isoforms of GSK3, was identified as a key regulator in tau-driven Alzheimer's disease.
Contraindications: Keep final DMSO concentration below 1%
Description: The GSK3β Assay Kit is designed to measure GSK3β activity for screening and profiling applications using Kinase-Glo® (Promega) as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: McCubrey JA., et al. Oncotarget 5(10): 2881-2911 (2014)
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