Product Type: Inhibitor
CAS No.: 504433-23-2
MolecularFormula: C17H13N3O
Molecular Weight: 275,3
Source: Synthetic
Purity: >99 %
Solubility: Soluble to 15 mM in DMSO
Appearance: Red solid
PubChem CID: 9943465
Scientific Background: GW 441756 is a potent and selective NGF receptor tyrosine kinase A (TrkA) inhibitor. Specifically, it is shown to block apoptosis and cell death induced by TrkA. GW-441756 displays > 100-fold selectivity over a range of other kinases.
References: 1. Wood E.R., et al. (2004) Bioorganic & Med. Chem. Ltr. 14(4): 953–957.2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.