Product Type: Inhibitor
CAS No.: 870483-87-7
MolecularFormula: C20H22N4O3
Molecular Weight: 366,4
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO: 10 mg/ml, clear (warmed)
Appearance: White to beige solid
PubChem CID: 11617559
Scientific Background: GW2580 is a potent and selective, ATP-competitive inhibitor of cFMS kinase. It also inhibits macrophage-colony stimulating factor receptor, M-CSF/ CSF-1. cFMS is a type III receptor tyrosine kinase that binds to M-CSF or CSF-1. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states.
References: 1. Conway J.G., et al. (2008) J. Pharm. Exp. Ther. 326(1): 41–50.2. Conway J.G., et al. (2005) Pro. Nat. Acad. Sci. USA. 102(44): 16078–16083.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.