Product Description: Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3].
Formula: C34H40Cl2N4O6
Citations: ACS Nano. 2023 Nov 21./Cancer Adv. 2024;7:e24021./Free Radic Biol Med. 2023 Jul 25;207:239-246./Nanyang Technological University. 2024./Pharmaceutics. 2023 Aug 3, 15(8), 2076./Chem Eng J. 390 (2020) 124521./Drug Deliv. 2022 Dec;29(1):3358-3369./FEBS Lett. 2021 Jan;595(2):206-219./Int J Mol Sci. 2022 Apr 11;23(8):4218./J Biol Chem. 2022 Aug 26;102417./Lasers Med Sci. 2020 Feb;35(1):71-78./Nat Biomed Eng. 2022 Dec 22./Nat Commun. 2022 Jun 16;13(1):3468./PLoS One. 2019 Sep 25;14(9):e0222331.
References: [1]Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31./[2]Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296./[3]Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53.
CAS Number: 17696-69-4
Molecular Weight: 671.61
Compound Purity: 95.0
Research Area: Cancer
Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Apoptosis;Endogenous Metabolite
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