Formulation: A lyophilized powder
Formal Name: L-α-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinylglycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinylglycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine, cyclic (7→23),(10→13),(11→19),(14→22)-tetrakis(disulfide), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C113H170N34O31S9 • XCF3COOH
Formula Weight: 2789,4
Shelf life (days): 1460
Notes: Hepcidin-25 is a peptide hormone that regulates iron homeostasis and has antibacterial activity.{64348} It is predominantly synthesized by hepatocytes and secreted into the circulation. Hepcidin-25 binds to ferroportin, a membrane-bound iron exporter expressed by macrophages, enterocytes, and hepatocytes, inducing ferroportin internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels. It is bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria, including P. aeruginosa, E. coli, K. pneumoniae, S. aureus, S. epidermidis, and E. faecium, when used at concentrations ranging from 6.25 to 50 µg/ml.{64349} Serum hepcidin-25 levels are increased in patients with chronic kidney disease (CKD).{64350}
English
Deutsch
