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Encompassing Amino Acids: 20-643
Application: Useful for SDS-PAGE and avidin-pull down assays.
Background: HER3 (human epidermal growth factor receptor 3, also known as ERB3) is a transmembrane protein encoded by the ERBB3 gene. HER3 is broadly expressed in human tissues. However, increased expression of HER3 has been linked to a variety of solid tumors including ovarian, breast, colon, and gastric cancers and correlates with decreased overall survival in colorectal cancer patients. HER3 has the unique property of being inherently catalytically inactive but still being able to participate in ligand binding, forming heterodimers with nearby receptors of the HER family. The formation of these dimers initiates a cascade of downstream signaling steps critical to cell proliferation. The binding and subsequent phosphorylation of HER3 by HER2 or EGFR (epidermal growth factor receptor, also known as HER1) has been found to play a role in tumor growth and drug resistance. Due to its cell surface expression in a variety of cancers and correlation with decreased survival, HER3 is a prospective therapeutic target for antibody-drug conjugate (ADC) development.
Description: Recombinant human HER3 (human epidermal growth factor receptor 3), encompassing amino acids 20-643 corresponding to the extracellular domain. This construct contains an Fc domain of IgG1 fused to the C-terminus, followed by a C-terminal Avi-Tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_001982.4
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Fc-Avi-Tag
Uniprot: P21860
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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