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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: Human HER4 kinase, also known as Erb-B4, Proto-Oncogene-Like Protein C-ErbB-4, and Tyrosine Kinase-Type Cell Surface Receptor when mutated has been implicated in cancer. There has also been connection to schizophrenia with single-nucleotide polymorphisms.
Description: The HER4 Assay Kit is designed to measure HER4 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The HER4 Assay Kit comes in a convenient 96-well format, with enough purified HER4, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Plowman, Gregory D., et al. "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family." Proceedings of the National Academy of Sciences 90.5 (1993): 1746-1750.
2. Elenius, Klaus, et al. "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation." The EMBO journal 16.6 (1997): 1268-1278.
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