Product Type: Inhibitor
CAS No.: 70563-58-5
MolecularFormula: C30H42N2O9
Molecular Weight: 574,3
Source: Synthetic
Purity: >98%
Solubility: Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Appearance: Yellow Solid
PubChem CID: 6436247
Scientific Background: Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
References: 1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370.2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537.4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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