Conjugation: HRP: Horseradish Peroxidase
Description of Target: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD
Key Reference: Malassine,A., (er) Retrovirology 5, 6 (2008)
Molecular Weight: 60kDa
Peptide Sequence: Synthetic peptide located within the following region:
TGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: HERV-FRD_6p24.1 provirus ancestral Env polyprotein
Protein Size: 538
Purification: Affinity Purified
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