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Encompassing Amino Acids: 163-562
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: HIPK3 (homeodomain interacting protein kinase 3) is a member of the HIPK family and is involved in apoptosis (1). JNK regulates the expression of HIPK3 in prostate cancer cells and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8 (2). HIPK3 has been reported to phosphorylate FADD and is implicated in multidrug resistance in a number of tumors. HIPK3 increases transcription factor SF-1 activity leading to increased steroidogenic gene expression in response to cAMP signaling.
Description: Recombinant human HIPK3 (a.a. 163-562), with N-terminal His-tag, expressed by Sf9 insect cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM sodium phosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol
Genbank: NM_005734
Host Cell Line: Sf9 cells
Purity: ≥85%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q9H422
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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