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Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: HIPK3 (Homeodomain Interacting Protein Kinase 3) is a serine/threonine protein kinase involved in the regulation of gene transcription induced by steroid hormones such as testosterone. Also known as ANPK (Androgen receptor-interacting nuclear protein kinase), it amplifies androgen receptor-mediated transcription. The kinase phosphorylates transcription factors JUN and RNUX2 and may decrease apoptosis through phosphorylation of FADD (FAS-associated death domain protein).
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The HIPK3 Kinase Assay Kit is designed to measure HIPK3 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant HIPK3 kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q9H422
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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