Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. HIST1H1T is a member of the histone H1 family. Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIST1H1T
Key Reference: Olsen,J.V., (2006) Cell 127 (3), 635-648
Molecular Weight: 22kDa
Peptide Sequence: Synthetic peptide located within the following region:
KLSKKVIPKSTRSKAKKSVSAKTKKLVLSRDSKSPKTAKTNKRAKKPRATProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Histone H1t
Protein Size: 207
Purification: Affinity Purified
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