Conjugation: HRP: Horseradish Peroxidase
Description of Target: HIST2H2BF is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIST2H2BF
Key Reference: Kim,S.C., (2006) Mol. Cell 23 (4), 607-618
Molecular Weight: 14kDa
Peptide Sequence: Synthetic peptide located within the following region:
MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Histone H2B type 2-F
Protein Size: 126
Purification: Affinity Purified
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