Products from BPS Bioscience require a minimum order value above 400€Encompassing Amino Acids: 2-136(end) with K27M mutation
Applications: Useful as a substrate for methyltransferases or acetyltransferases and for screening inhibitors and selectivity profiling for drug discovery.
Description: Human Histone 3(HIST1H3E), GenBank Accession No.NM_003532, a.a. 2-136(end) with K27Mmutation and N-terminal His-tag, MW =16.2 kDa, expressed in an E. coliexpression system.
Format: Aqueous buffer solution
Formulation: 8 mM PBS pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol
Genbank: NM_003532
Host Cell Line: E. coli
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: P68431
Warnings: Avoidfreeze/thaw cycles. Storing diluted proteinis not recommended, if necessary, usecarrier protein (BSA 0.1 - 0.5%).
Biosafety Level: Not applicable (BSL-1)
References: 1. Loyola, A., et al., Mol. Cell. 2006; 24(2): 309-316.
2. Khuong-Quang, D-A., et al., Acta. Neuropathol. 2012; 10.1007/s00401-012-0998-0.Application Reference(s):
Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)
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