Histone H4 (2-58), GST-tag Recombinant

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Encompassing Amino Acids: 2-58

Applications: Useful as a substrate for methyltransferases or acetyltransferases and for screening small molecular inhibitors of histone methyltransferases for drug discovery.

Description: Human Histone 4 (GenBank Accession No. NM_003548), a.a. 2-58 with N-terminal GST-tag, MW = 32 kDa, expressed in an E. coli expression system.

Format: Aqueous buffer solution

Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione

Genbank: NM_003548

Host Cell Line: E. coli

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal GST-tag

Uniprot: P62805

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Kornberg, R.D. (1977) Annu. Rev.
Biochem., 46, 931-954.
2. van Holde, K.E. (1989) Chromatin, 1-497.Application Reference(s):
1. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)
2. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury (2013)

• SKU: BPS52019
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 52019
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK