Formulation: A solid
Formal Name: N6-carbamoyl-L-lysine-2,6,6-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C7H12D3N3O3
Formula Weight: 192,2
Shelf life (days): 1460
Notes: Homocitrulline-d3 is intended for use as an internal standard for the quantification of homocitrulline (Item No. 34980) by GC- or LC-MS. Homocitrulline is an amino acid and a product of carbamylation, a post-translational modification of proteins and amino acids.{34536,34533} It is formed by the adduction of isocyanic acid, a product of urea degradation or thiocyanate oxidation induced by myeloperoxidase (MPO), to the ε-amino group of lysine residues.{34533} Protein-bound homocitrulline levels are increased in the aortas of transgenic Ldlr-/- mice expressing human MPO fed a high-fat atherogenic diet.{32815} Intra-articular injection of homocitrulline-containing peptides induces the development of arthritis in mice.{32805} Homocitrulline-containing peptide and anti-homocitrulline antibody levels are increased in whole blood from patients with erosive rheumatoid arthritis compared to patients with non-erosive rheumatoid arthritis.
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