Application Note: WB: 1:2000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 21
Specificity/Sensitivity: chicken, Xenopus, Drosophila, and zebrafish
Form: Liquid
Buffer (with preservative): Filter-sterilized 0.12M Sodium Phosphate buffer (pH7.4), 50% Glycerol, no preservative.
Concentration: 0.75 mg/ml (Please refer to the vial label for the specific concentration.)
Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot ID: Q13185
Antigen Species: Human
Immunogen: The product is prepared by immunizing rabbit with the synthetic peptide WHSCPEDEAQ-C corresponding to the C-terminal sequence of human HP1 gamma and purified by affinity purification with the peptide.
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: chromobox 3
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