hSMG-1 inhibitor 11j, CAS 1402452-15-6

Product Description: hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].

Applications: Cancer-Kinase/protease

Formula: C27H28ClN7O3S

References: [1]Gopalsamy A, et, al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.

CAS Number: 1402452-15-6

Molecular Weight: 566.07

Compound Purity: 99.82

Research Area: Cancer

Solubility: DMSO : 80 mg/mL (ultrasonic)

Target: CDK;GSK-3;mTOR;PI3K

• SKU: MEXHY-124719-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124719-25
• Package Unit: 25 mg
• Quantity Unit: STK