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Encompassing Amino Acids: 2-641
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: In cooperation with other chaperones, Hsp70 stabilizes preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
Description: Human Heat Shock Protein 70 (GenBank Accession No. NM_005345), a.a. 2-641 with C-terminal His-tag, MW = 71 kDa, expressed in E. coli.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 200 mM imidazole
Genbank: NM_005345
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: P08107
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lee K.J. et al., Exp. Mol. Med. 40 (6), 658-668 (2008).
2. Birtas-Atesoglu E. et al., Clin. Exp. Rheumatol. 26, S96-S98 (2008).
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