Conjugation: HRP: Horseradish Peroxidase
Description of Target: HTRA4 is a member of the HtrA family of proteases. The protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HTRA4
Key Reference: Clausen,T., (2002) Mol. Cell 10 (3), 443-455
Molecular Weight: 51kDa
Peptide Sequence: Synthetic peptide located within the following region:
LKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Serine protease HTRA4
Protein Size: 476
Purification: Affinity Purified
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