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Background: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Description: The Human Thrombin was activated from homogeneous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. These activating enzymes were removed after activation. Complete activation was observed on SDS-PAGE. MW = 37 kDa.
Format: Aqueous buffer solution
Formulation: 50 mM sodium citrate, 0.2 M NaCl, 0.1% PEG-8000, pH 6.5
Purification: Purified from human plasma that was tested and found negative by FDA-accepted methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).
Purity: ≥90% by SDS-PAGE
Storage Stability: At least 6 months at -80°C.
Supplied As: Supplied as 0.33 mg total protein in 0.096 ml
Uniprot: P00734
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Spronk HM, et al. 2013. Curr Atheroscler Rep. 15(11):363.
2. Huntington JA. 2013. J Thromb Haemost. Suppl 1:254-64.
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