Background: This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Description: Recombinant human CD48 protein with C-terminal mouse Fc and 6×His
Molecular Weight: The protein has a predicted molecular mass of 69-72 kDa after removal of the signal peptide.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Mouse Fc and 6×His Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: CD48
Uniprot ID: P09326
Usage: Research use only
Molecular Characterization: CD48(Gln27-Ser220) mFc(Pro99-Lys330) 6×His
Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
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