Species: Human
Application Note: Binding assay: Measured by its binding ability in a functional ELISA with Folic Acid-BSA. The ED₅₀ range ≤ 5 μg/ml.
Calculated MW: 29
Form: Liquid
Buffer (with preservative): PBS, 10% Glycerol, no preservative.
Concentration: 0.25 mg/ml (Please refer to the vial label for the specific concentration.)
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Background: The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P14207
Region Sequence: His-Tagged; 22-230aa (P14207, NP_000794.3)
ExpressionSystem: HEK293 cells
Conjugation: Unconjugated
Full Name: folate receptor beta
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