Species: Human
Form: Liquid
Buffer (with preservative): 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 50% Glycerol, 2mM DTT, 250mM Imidazole, no preservative.
Concentration: 0.25 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot ID: P52926
Region Sequence: Full length protein, C-terminal His-Tag; MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH
ExpressionSystem: E. coli
Conjugation: Unconjugated
Full Name: high mobility group AT-hook 2
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