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Background: IgM (immunoglobulin M), also known as macro-immunoglobulin, is an immunoglobulin isotype found in vertebrates in response to an initial exposure to an antigen. Iti s produced first in B cells as a membrane protein and later in plasma cells as a secreted pentamer (5 monomers adjoined by another protein called the J chain) or hexamer. IgM is a potent inhibitor of pathogens and trigger complement responses. IgM is also involved in the recognition and targeting of self-antigens or neo-epitopes for cell removal, as in the case of the recognition of phosphorylcholine, single and double stranded RNA, amongst others. In contrast to IgG, IgM does not bind to Fc gamma receptors and cannot trigger ADCC (antibody-dependent cellular cytotoxicity). IgM is being tested as therapeutic agent for the treatment of sepsis, cancer, GvHD (graft versus host disease) and MS (multiple sclerosis). Further studies are necessary to access the full potential of using IgM in the development of auto-inflammatory and cancer treatments.
Contraindications: The IgM Colorimetric ELISA Kit is compatible with up to 1% final DMSO concentration.
Description: The IgM Colorimetric ELISA Kit is designed to detect and quantify protein levels of human IgM pentamers captured by pre-matched antibody pairs. This assay kit comes in a convenient 96-well format, with a pre-coated Anti-IgM-specific antibody plate, enough recombinant purified IgM standard, and detection reagents for 100 wells.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Biosafety Level: Not applicable (BSL-1)
References: Vidarsoon G, et al., 2014 Front. Immunol. 5:00520. Keyt B., et al., 2020 Antibodies (Basel) 9(4): 53.
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