Species: Human
Application Note: Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED₅₀ range ≤ 0.5 ng/ml.
Calculated MW: 17
Form: Liquid
Buffer (with preservative): PBS, 10% Glycerol, no preservative.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Background: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot ID: P05112
Region Sequence: His-Tagged, 25-153aa (P05112, NP_000580)
ExpressionSystem: HEK293 cells
Conjugation: Unconjugated
Full Name: interleukin 4