Species: Human
Application Note: The specific activity was found to be 6,200 U/mg. One unit is defined as the digestion of 1 μg Azocoll/min at 37ºC.
Calculated MW: 30
Form: Liquid
Buffer (with preservative): 10mM HEPES (pH7.4), 5mM CaCl₂, 150mM NaCl, no preservative.
Concentration:
Background: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Uniprot ID: P09237
ExpressionSystem: E. coli
Purification: Purified by proprietary chromatographic techniques
Conjugation: Unconjugated
Full Name: matrix metallopeptidase 7
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