Product Type: Inhibitor
CAS No.: 102518-79-6
MolecularFormula: C15H18N2O
Molecular Weight: 242,32
Source: Synthetic
Purity: >95% (HPLC); NMR (conforms)
Solubility: Soluble in DMSO, methanol or ethanol.
Appearance: Off-White solid
PubChem CID: 44461111
Scientific Background: Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer's disease is under studies (1-3). Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate (4).
References: 1. Bai Dl., Tang Xc., He YC., Curr MedChem. (2000) 7(3): 355-74.2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.