Hydroxyfasudil, CAS 105628-72-6

Formulation: A solid

Formal Name: 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone

Purity: ≥98%

Formula Markup: C14H17N3O3S

Formula Weight: 307,4

Shelf life (days): 1460

CAS Number: 105628-72-6

Notes: Hydroxyfasudil is an inhibitor of ROCK1 and ROCK2 (IC50s = 0.15 and 0.57 µM, respectively) and an active metabolite of the Rho-associated kinase (ROCK) inhibitor HA-1077 (fasudil; Item No. 10010559).{72376} In vivo, hydroxyfasudil (3 and 10 mg/kg) decreases blood viscosity and prevents cerebral vasospasm in a canine model of subarachnoid hemorrhage.{72377} Hydroxyfasudil also reverses hypertension-associated dysfunction of relaxation induced by nitric oxide in corpus cavernosum smooth muscle in spontaneously hypertensive rats.{72378}

• SKU: CAY40814-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40814-5
• Package Unit: 5 mg
• Quantity Unit: STK