Formulation: A solid
Formal Name: 1,9-dihydro-1,9-d2-6H-purin-6-one-2,8-d2
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C5D4N4O
Formula Weight: 140,1
Shelf life (days): 1460
CAS Number: 2483831-32-7
Notes: Hypoxanthine-d4 is intended for use as an internal standard for the quantification of hypoxanthine (Item No. 22254) by GC- or LC-MS. Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain.{39146} Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice.{39147} Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysunction, self-mutilation, and hyperuricemia.
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