Formulation: A solution in ethanol
Formal Name: 3-(octyloxy)-2,2-bis((octyloxy)methyl)propyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)butanoate
Purity: ≥95%
Formula Markup: C39H78N2O6
Formula Weight: 671
Shelf life (days): 730
Notes: IAJD249 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.35).{67543} It co-assembles with mRNA to form dendrimersome nanoparticles (DNPs) in acetate buffer. IAJD249 co-assembled with luciferase mRNA delivers the mRNA to the spleen, liver, lungs, and lymph nodes in mice.