Product Type: Inhibitor
CAS No.: 847591-62-2
MolecularFormula: C33H32N4O4
Molecular Weight: 548,63
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
Appearance: White solid
PubChem CID: 11238147
Scientific Background: Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
References: 1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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