Calculated MW: 21
Specificity/Sensitivity: GTX02957 (MT86/MT221) is able to detect native and recombinant human p40 subunit of IL-12 and IL-23. In combination with GTX02983-02 (MT155), it recognizes IL-23 heterodimer (p40 + p19).
Form: Liquid
Concentration:
Background: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Uniprot ID: Q9NPF7
Full Name: interleukin 23 subunit alpha
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