Abbreviation: IL6ST
Target Synonym: IL6ST;CD130;CDW130;GP130;IL-6RB
Conjugation: Unconjugated
UNIProt ID: P40189
Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human IL6ST
Dilution: WB 1:500-1:2000,IF 1:50-1:200
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