More than 580 SARS-CoV-2 products in our shop

 

We offer an extensive range of research reagents to support the SARS-CoV-2 studies. Please see below the products for SARS-CoV-2 research, from antibodies to proteins and additional reagents like viral transport medium or ELISA kit to measure cytokine storm. For the detection of SARS-CoV-2, we have ELISA and PCR kits as well as an antibody rapid test.

 

SARS-CoV-2 Specific Reagents

 

Monoclonal Antibodies

  • Clone CR3022 anti SARS-COV neutralizing antibody which cross reacts with SARS-CoV2.
  • Spike protein precursor is cleaved into glycosylated subunits, S1 and S2 (S2’). S1 binds to the host’s receptor, ACE2, while S2 mediates viral and host membrane fusion.
  • Nucleocapsid binds viral genomic RNA and forms a helical ribonucleocapsid. Involved in genome protection, viral RNA replication, virion assembly, and immune evasion. Interacts with M and nsp3 proteins.
  • NSP8 is thought to be part of the viral replication complex, which is associated with intracellular membranes.
  • ORF7a is a type I membrane protein that interacts with bone marrow stromal antigen 2 (BST-2) in SARS-CoV. ORF7a binding inhibits BST-2 glycosylation and interferes with this restriction activity.
  • ACE2 has been shown to be a functional receptor of SARS CoV-2.
  • TMPRSS2 a serine protease, is a critical factor in the priming of the SARS-CoV-2 spike protein. This is an essential step for viral entry into host cells through fusion of the viral and cellular membranes.
  • Convalescent Patient Antibodies

Monoclonal Conjugated Antibodies

Polyclonal Antibodies

Recombinant Antibodies
Spike
Nucleocapsid
ACE2
TMPRSS2

Spike
Nucleocapsid
Membrane
ACE2
TMPRSS2
ORF7a
ORF8
other polyclonal AB

NSP1
NSP3
NSP5
NSP8
NSP9
NSP10
NSP12
NSP13
NSP16

 Clon CR3022
Spike
Nucleocapsid
Protein conjugated

Recombinant Proteins

Proteins

FFPE Cell Pellet Block

Cell pellet consists of 293T cells overexpressing different SARS-CoV-2 proteins:

 

CELL LYSATES

Whole-cell lysate of 293T cells overexpressing different SARS-CoV-2 proteins:

SARS-CoV-2 Pseudoviral Particles

These SARS-COV-2 pseudoviral particles works perfectly for Luc pseudovirus to get robust signal for screening potential inhibitors to block SARS-CoV-2 entry and viral protein translation with spike protein of SARS-CoV-2; and for measuring the activity of and screening for neutralizing antibody against SARS-CoV-2. Experiments can be performed in a BSL-2 laboratory.

 

SARS-CoV-2 Receptors

It is well known, that the entry is mediated by the binding of the spike proteins to ACE2 and that the proteins are primed by TMPRSS2. However, COVID-19 infections can also lead to neurological squeals. The cellular receptor Neuropilin-1, which binds furin–cleaved substrates could play a potential in central nervous system infection. Here you can find Neuropilin-1 antibodies and proteins for your research.

 

Detection Kits

 

SARS-CoV-2 Additional reagents

Lectins

Mannose-binding lectins interfere with the coronavirus entry process by binding to the high-mannose type N-glycans of SARS-CoV via the S protein, preventing viral attachment to the host cell.

Transport Media

It is formulated using the final ingredient concentrations outlined in CDC's SOP#: DSR-052-01 “Preparation of viral transport medium”. Isotonic solution at neutral pH containing protective proteins, antibiotic to prevent microbial growth, and anti-mycotic to prevent contamination by yeast and fungi.

Secondary Antibodies

ELISA Kits

For the quantitative determination of human ACE2 concentrations in serum, plasma, cell culture supernates and other biological fluids.
Accumulating research evidence indicates that many patients with severe COVID-19 might have a cytokine storm syndrome.

Cell Lines

In vitro experiments using cell lines for drug screening can greatly improve the speed of screening anti-SARS-CoV-2 drugs.

Camostat mesylate

Inhibits influenza virus replication in human tracheal epithelial cells. Reduces infection of Calu-3 lung cells by SARS-CoV-2 via inhibition of the serine proteaseTMPRSS2 required for viral spike protein priming.

Viral Nucleic Acid Extraction Kit

For in vitro diagnostic use. RIDA® Xtract is a spin-filter based extraction kit for the simultaneous isolation and purification of high quality bacterial and viral DNA as well as viral RNA from human serum, plasma specimen, cerebral fluid, cell culture supernatant, other cell free body fluids (e.g. urine), swabs, tissue biopsies and stool specimen.

Proteinase K

Proteinase K is a kind of high activity Proteinase of subtilisin, which is used to degrade proteins in biological samples. It is used to digest RNA before the extraction.

Vectastain ABC reagents

Vectastain ABC reagents were recently used to visualize detectable virus in several organs of an infected animal host and ACE2/TMPRSS2 in ocular surface cells. [Kim, Y. et al. Infection and Rapid Transmission of SARS-CoV-2 in Ferrets. Cell Host & Microbe (2020) and Zhou, L. et al. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. The Ocular Surface (2020)]

Picture from Zhou et al. Expression and localization of TMPRSS2 in conjunctiva in post-mortem globe.
Conjunctiva from three separate globes are depicted (A-B, C­-D). Staining was performed with
VECTASTAIN ABC kit.

Vectashield antifade mounting media

To investigate infection routes of the coronaviruses VECTASHIELD antifade mounting media were used to maximize signal retention for imaging and data evaluation. This approach relies primarily on immunofluorescent visualization. Studies by Zhou, J. et al. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Science Advances (2017) and more recently Lamers, M. M. et al. SARS-CoV-2 productively infects human gut enterocytes. Science (2020) and Monteil, V. et al. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell (2020) utilized human organoids to show both Middle East respiratory syndrome (MERS) coronavirus and SARS-CoV-2 infect gut and kidney cells.

Picture from Lamers et al. Immunofluorescent staining of SARS-CoV-2 infected intestinal organoids.
Staining retained with VECTASHIELD antifade mounting medium.