Formulation: Lyophilized from sterile PBS, pH 7.4, with 5% trehalose, 5% mannitol, and 0.01% Tween 80
Purity: ≥90% as determined by SDS-PAGE
Shelf life (days): 365
Notes: Inhibin beta E chain (INHBE) is a member of the TGF-β superfamily.{67279} INHBE encodes a 350-amino acid pre-protein, which is proteolytically cleaved at Thr237 to release the mature INHBE peptide, and is a secreted protein mainly expressed in the liver. It exists as a homodimer, also known as activin E, or forms heterodimers with other inhibin beta chains such as INHBC.{67280} INHBE is a hepatokine that is involved in hepatocyte viability, thermogenesis, and insulin sensitivity and binds to follistatin (Item No. 31839).{67280,67281,67279} Overexpression of INHBE induces apoptosis in hepatocytes and INHBE-containing conditioned medium induces expression of genes involved in adipocyte differentiation, which can be blocked by the activin receptor-like kinase (ALK) inhibitor SB-431542 (Item No. 13031).{67280,67281} Hepatic expression of human INHBE decreases plasma glucose levels and increases body temperature in mice.{67281} Loss-of-function mutations in INHBE are associated with favorable body fat distribution and a decreased risk of developing type 2 diabetes.{67282} Increased tumor levels of INHBE positively correlate with increasing tumor grade and negatively correlate with poor overall survival in patients with clear-cell renal cell carcinoma (ccRCC).{67283} Cayman’s INHBE (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of INHBE (amino acids 237-350) fused to human IgG1 Fc at its N-terminus, consists of 374 amino acids and has a calculated molecular weight of 40.9 kDa.
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