Formulation: A solid
Purity: ≥98%
Formula Markup: C10H12N4O5
Formula Weight: 268,2
Shelf life (days): 1460
CAS Number: 58-63-9
Notes: Inosine is a purine nucleoside composed of hypoxanthine (Item No. 22254) and ribose.{58936} It is formed from inosine-5'-monophosphate (Item No. 18135) by 5'-nucleotidase.{58937} Inosine can also be formed by the deamination of adenosine, a post-translational modification known as A-to-I editing that occurs in tRNA and mRNA and is catalyzed by adenosine deaminase acting on RNA (ADAR).{58936} It inhibits the production of TNF-α, IL-1, and IL-12 in LPS-stimulated isolated mouse peritoneal macrophages when used at concentrations ranging from 30 to 1,000 µM.{58938} Inosine reduces sensorimotor impairments in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered as a continuous infusion into the cisterna magna via osmotic minipump.{58939}
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