inS3-54-A18, CAS 328998-53-4

Formulation: A solid

Formal Name: 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-2H-pyrrol-2-one

Purity: ≥98%

Formula Markup: C23H16ClNO2

Formula Weight: 373,8

Shelf life (days): 1460

CAS Number: 328998-53-4

Notes: inS3-54-A18 is an inhibitor of STAT3.{51546} It selectively inhibits the binding of STAT3 to DNA over STAT1 at 25 µM. inS3-54-A18 (20 µM) inhibits STAT3 activity in a reporter assay using MDA-MB-231 breast cancer cells. It induces apoptosis in, and reduces migration and invasion of, A549 non-small cell lung cancer (NSCLC) and MDA-MB-231 cells when used at concentrations of 5 or 10 µM. inS3-54-A18 (200 mg/kg) reduces tumor volume in an A549 mouse xenograft model.

• SKU: CAY39678-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39678-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK