Clone Name: NKI-GoH3
Application Note: FACS: 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 127
Form: Liquid
Buffer (with preservative): PBS, 1% BSA, 5% Sucrose, 0.09% Sodium Azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot ID: P23229
Antigen Species: Mouse
Immunogen: BALB/c mouse mammary tumor cells
Purification: Purified by affinity chromatography
Conjugation: PE
Full Name: integrin subunit alpha 6
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