IOX1, CAS 5852-78-8

JMJD inhibitor

Product Type: Inhibitor

CAS No.: 5852-78-8

MolecularFormula: C10H7NO3

Molecular Weight: 189,2

Source: Synthetic

Purity: ≥98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (20 mg/ml)

Appearance: Yellow powder

PubChem CID: 459617

Scientific Background: IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).

References: 1. King O.N., et al. (2010) PLoS One. 5: e15535.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-377-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-377-5MG
• Package Unit: 5 mg
• Quantity Unit: STK