Formulation: A solid
Formal Name: glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-L-aspartic acid, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C101H164N24O28S • XCF3COOH
Formula Weight: 2194,6
Shelf life (days): 1460
Notes: Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20) is a dodecapeptide fragment of IRBP, also known as retinoid-binding protein 3, which is involved in pigment regeneration by transporting retinol and retinal from photoreceptor cells to the retinal pigment epithelium.{51410,51411} IRBP1-20 has been used to induce autoimmune uveoretinitis in C57BL/6 mice, which bear the H-2b haplotype.{51411} IRBP1-20 (3 µM) increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes. Immunization and rechallenge with IRBP1-20 increases ear swelling, ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in IFN-γ-deficient mice.
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