IRF1-IN-1, CAS 701225-07-2

Product Description: IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].

Applications: COVID-19-anti-virus

Formula: C22H24N4O4S

References: [1]Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21(8):856-872.

CAS Number: 701225-07-2

Molecular Weight: 440.52

Compound Purity: 99.72

Research Area: Infection; Inflammation/Immunology

Target: Caspase;IFNAR;Interleukin Related;PARP;Pyroptosis

• SKU: MEXHY-171006-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171006-50
• Package Unit: 50 mg
• Quantity Unit: STK