Product Type: Inducer
CAS No.: 100286-90-6
MolecularFormula: C33H38N4O6•HCl
Molecular Weight: 623,14
Source: Synthetic
Purity: >98%
Solubility: Soluble to 50 mg/ml in DMSO
Appearance: Yellow solid
PubChem CID: 74990
Scientific Background: Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).
References: 1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388.2. O'Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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