Formulation: A solid
Formal Name: 7-methoxy-8-(3-methyl-2-oxobutyl)-2H-1-benzopyran-2-one
Purity: ≥98%
Formula Markup: C15H16O4
Formula Weight: 260,3
Shelf life (days): 1460
CAS Number: 1088-17-1
Notes: Isomeranzin is a coumarin that has been found in C. grandis and has antioxidant and anti-inflammatory activities.{66080,66081} It inhibits superoxide anion generation in, and elastase release from, isolated human neutrophils stimulated with cytochalasin B (Item No. 11328) and fMLP (IC50s = 3.89 and 4.33 µM, respectively).{66080} Isomeranzin (30 µM) inhibits LPS-induced nitric oxide (NO) release in RAW 264.7 macrophages.{66081} It improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) when administered at a dose of 30 mg/kg.
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